What is Capsaicin Treatment?
Capsaicin is the active compound found in chili peppers that gives them their heat. In medical applications, high-concentration capsaicin is used to treat neuropathic pain by desensitizing the nerve endings in the skin. This treatment works by depleting substance P, a neurotransmitter that sends pain signals to the brain.
High-concentration capsaicin treatments are applied in a medical setting and can provide lasting pain relief for peripheral neuropathy. Unlike over-the-counter capsaicin creams, prescription-strength capsaicin patches deliver a therapeutic dose that can provide relief lasting up to 3 months from a single application.
Conditions Treated
Diabetic Neuropathy
Burning, tingling, and pain in the feet caused by diabetes-related nerve damage.
Post-Herpetic Neuralgia
Persistent nerve pain following a shingles outbreak.
HIV-Associated Neuropathy
Peripheral neuropathy associated with HIV infection or treatment.
Other Peripheral Neuropathies
Various causes of localized neuropathic pain in the extremities.
The Treatment Process
Preparation
A topical anesthetic is applied to the treatment area to minimize discomfort during the procedure.
Application
The high-concentration capsaicin patch is applied to the painful area and left in place for 30-60 minutes.
Removal & Cleansing
The patch is removed and the area is cleansed. You may experience temporary warming or burning sensations.
Results
Pain relief typically begins within 1-2 weeks and can last up to 3 months. Treatment can be repeated as needed.
Benefits of Capsaicin Treatment
- Non-invasive, topical treatment
- Long-lasting relief from single application (up to 3 months)
- No systemic side effects like oral medications
- Can be combined with other treatments
- Reduces need for daily pain medications
- Can be repeated every 3 months if needed
What to Expect
During the treatment, you may feel warmth, stinging, or burning at the application site—this is normal and indicates the capsaicin is working. These sensations typically decrease within a few days. Some patients experience temporary redness or swelling at the treatment site.
Pain relief develops gradually over 1-2 weeks as the nerve endings become desensitized. Most patients notice significant improvement that lasts up to 3 months, at which point the treatment can be repeated.